[CIS PIDD] [cis-pidd] Low NK function question

[CIS-PIDD]

Hi All,

I recently graduated from A/I fellowship and now seeing patients at a
private practice. We recently saw a 49 year old Japanese female with
recurrent episodes of shingles at the age of 25, 30 and 49 and a history of
recurrent mumps-like illness during childhood. No other significant
infections or significant PMH.

Quantitative immunoglobulins and lymphocyte subsets/% including NK cells
were normal. CBC normal with no monocytopenia. However, NK cell function
(via Quest labs) was low at 5 LU30 (decreased activity <7, normal activity
7-125). This was repeated with the same result.

She has undetectable titers to HSV and CMV. Is there anything else that we
can offer this patient? Prophylaxis? How should we proceed? Would
appreciate any thoughts! Thanks in advance,

-- 
Jennifer Toh, M.D.
Associate
Adult & Pediatric Allergy, Immunology, Asthma & Sinus Disease
New York Allergy and Asthma, PLLC
261 East 78th St., Floor 4, New York, NY 10075
Tel: 212 517-3300, Fax: 212 517-3303

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