[CIS PIDD] [cis-pidd] C4 deficiency, Cryoglobulinemia and Hypogammaglobulinemia

[CIS-PIDD]

I had such a case recovering from marginally successful gene tx for ADA-SCID. I treated with steroids and the rash resolved, but the child's immunity was recovering from chemotherapy and PEG-ADA withdrawal, so the clinical situations are not entirely analogous
-R


--
Rob Sokolic, MD
Medical Officer
Center for Biologics Evaluation and Research
Office of Tissues and Advanced Therapies
U.S. Food and Drug Administration
Tel: 240-402-5564
Robert.Sokolic at fda.hhs.gov<mailto:Robert.Sokolic at fda.hhs.gov>
[cid:image001.png at 01D1C57E.DFA022A0]<http://www.fda.gov/>

[cid:image002.jpg at 01D1C57E.DFA022A0]<https://www.facebook.com/FDA>  [cid:image003.jpg at 01D1C57E.DFA022A0] <https://twitter.com/US_FDA>   [cid:image004.jpg at 01D1C57E.DFA022A0] <http://www.youtube.com/user/USFoodandDrugAdmin>   [cid:image005.jpg at 01D1C57E.DFA022A0] <http://www.flickr.com/photos/fdaphotos/>   [cid:image006.jpg at 01D1C57E.DFA022A0] <http://www.fda.gov/AboutFDA/ContactFDA/StayInformed/RSSFeeds/default.htm>

The above transmission is meant solely for the addressee. The information contained in this message may be of a private, medical, privileged or industrial nature, and may not be communicated beyond the initial recipient. If you are not the intended recipient of this message or the agent of such recipient, please destroy all physical copies of this message, delete all electronic copies and notify the sender of the error.

This communication does not constitute a written advisory opinion under 21 CFR 10.85, but rather is an informal communication under 21 CFR 10.85(k) which represents my best judgment at this time, but does not necessarily represent the formal position of FDA, and does not bind or otherwise obligate or commit the agency to the views expressed.


From: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Sent: Wednesday, November 30, 2016 7:14 AM
To: CIS-PIDD
Subject: Re: AW: [cis-pidd] C4 deficiency, Cryoglobulinemia and Hypogammaglobulinemia

We are dealing with a similar 5 year old with AT and progressive skin lesions . Skin biopsy sent to Kate Sullivan to look for Rubella...not sure what it means if positive..considering starting Humira



Erwin W. Gelfand, M.D.
Chairman, Department of Pediatrics
National Jewish Health
1400 Jackson Street
Denver, CO 80206
Ph: 303-398-1196
Fax: 303-270-2105
E-mail: gelfande at njhealth.org<mailto:gelfande at njhealth.org>

From: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Reply-To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Date: Tuesday, November 29, 2016 at 11:33 PM
To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Subject: AW: [cis-pidd] C4 deficiency, Cryoglobulinemia and Hypogammaglobulinemia

Dear colleagues,
I am following a seven year old patient with ataxia teleangiectasia and skin granuloma positive for rubella vaccine virus. Granuloma slowly increase in size and significantly contribute to reduced quality of life. Parents are at present not considering hematopoetic stem cell transplantation as a therapeutical option. Does anyone have experience in treating these granulomas with e.g. antiviral drugs or interferons?
Yours sincerely,
Fabian Hauck

Fabian Hauck, MD, PhD

Attending physician / Head Immunodeficiency Unit and Immunological Diagnostics Laboratoy
Pediatrics / Pediatric Hematology and Oncology / Immunology (DGfI)

Dr. von Hauner Children's Hospital
Klinikum der Universität München
Lindwurmstr. 4, 80337 München
Germany

Tel.: +49 89 4400-53931
Fax: +49 89 4400-53964
E-Mail: fabian.hauck at med.uni-muenchen.de<mailto:fabian.hauck at med.uni-muenchen.de>


www.klinikum.uni-muenchen.de<http://www.klinikum.uni-muenchen.de/>

[cid:image001.png at 01D088A4.85EC62E0]

Das Klinikum der Universität München ist eine Anstalt des öffentlichen Rechts (AöR)
The Klinikum der Universität München is an Institution under Public Law



---

You are currently subscribed to cis-pidd as: gelfande at njhealth.org<mailto:gelfande at njhealth.org>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396547.ce55188acfe7ac06c89e6d79f145cfcf&n=T&l=cis-pidd&o=4030870

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-4030870-96396547.ce55188acfe7ac06c89e6d79f145cfcf at lyris.dundee.net<mailto:leave-4030870-96396547.ce55188acfe7ac06c89e6d79f145cfcf at lyris.dundee.net>

NOTICE: This email message is for the sole use of the intended recipient(s) and may contain confidential and privileged information. Any unauthorized review, use, disclosure or distribution is prohibited. If you are not the intended recipient, please contact the sender by reply email and destroy all copies of the original message.  ­­

---

You are currently subscribed to cis-pidd as: Robert.Sokolic at fda.hhs.gov<mailto:Robert.Sokolic at fda.hhs.gov>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396896.aa2a546ec4607db5083cfc5e6c9c7870&n=T&l=cis-pidd&o=4031378

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-4031378-96396896.aa2a546ec4607db5083cfc5e6c9c7870 at lyris.dundee.net<mailto:leave-4031378-96396896.aa2a546ec4607db5083cfc5e6c9c7870 at lyris.dundee.net>

---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=4031735
or send a blank email to leave-4031735-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image002.png
Type: image/png
Size: 4087 bytes
Desc: image002.png
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0002.png>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image003.jpg
Type: image/jpeg
Size: 754 bytes
Desc: image003.jpg
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0005.jpg>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image004.jpg
Type: image/jpeg
Size: 776 bytes
Desc: image004.jpg
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0006.jpg>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image005.jpg
Type: image/jpeg
Size: 784 bytes
Desc: image005.jpg
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0007.jpg>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image006.jpg
Type: image/jpeg
Size: 790 bytes
Desc: image006.jpg
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0008.jpg>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image007.jpg
Type: image/jpeg
Size: 736 bytes
Desc: image007.jpg
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0009.jpg>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image008.png
Type: image/png
Size: 6012 bytes
Desc: image008.png
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20161130/0602011c/attachment-0003.png>