[CIS PIDD] [cis-pidd] Eye disease in CVID

[CIS-PIDD]

Dear Panida

We've used topical IgG in XLA. Our method is described here.

https://www.ncbi.nlm.nih.gov/m/pubmed/8933411/

Best wishes

John


_________________________
Professor John B. Ziegler, AM
Department of Immunology & Infectious Diseases
Sydney Children's Hospital
High St., Randwick NSW 2031
Australia
T: (02) 93821515
F: + 61 + 2 93821580
E: j.ziegler at unsw.edu.au<mailto:j.ziegler at unsw.edu.au>

On 1 Dec 2016, at 3:17 AM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>> wrote:

Dear colleagues,

We have a 55-yo white female with CVID, who has suffered from severe bilateral blepharitis, episcleritis, and dry eye for 2 years now to the point that she has lost all eyelashes. So far there is no evidence of uveitis or retinal diseases. No improvement from steroids eye drops or oral.

Her ophthalmologist is at a loss in how to proceed. I was wondering if her eyelid and scleral diseases are related to CVID. She is otherwise doing well from infection standpoint, IgG levels >1,000 on IVIG, IgA 10s, and IgM 20-30s. She does not have dry mouth, autoimmune manifestations, or lymphoid infiltrations. Her T, B cell counts and their subsets are normal.

Does anyone have experience with CVID patients like this? I would appreciate comments or suggestions. I looked up the literature and most reports of eye diseases in CVID are more of uveitis or retinal diseases, similar to those seen in sarcoidosis.

Thank you,
Panida

Panida Sriaroon, MD
Associate Professor
Associate Director, Fellowship Program
Medical Director, USF/All Children's Hospital Allergy/Immunology clinic
E-mail  psriaroo at health.usf.edu<mailto:psriaroo at health.usf.edu>



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