[CIS PIDD] [cis-pidd] Hyper IgA
CIS-PIDD
cis-pidd at lists.clinimmsoc.org
Tue Dec 6 14:25:44 EST 2016
Dear professors and colleagues,
Two additional considerations might be:
XL-EDA-ID, and
Hepatic Veno-occlusive disease with Immunodeficiency.
Best regards,
Saul
2016-12-06 13:18 GMT-06:00 CIS-PIDD <cis-pidd at lists.clinimmsoc.org>:
> Colleagues:
>
>
>
> A likely *in*complete list of disorders associated with elevated IgA
> include:
>
>
>
> Myeloma
>
> Autoimmune disease (RA, SLE)*
>
> Chronic liver disease*
>
> Chronic infection*
>
> Sarcoidosis*
>
> Wiscott-Aldrich
>
> Obesity/metabolic syndrome*
>
> Celiac/gluten enteropathy*
>
> HSP
>
> Hyper IgD syndrome*
>
> Acute Kawasaki syndrome
>
>
>
> *Consider in current patient?
>
>
>
> Joe Church
>
> Children’s Hospital Los Angeles
>
>
>
> *From:*
>
> CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
> *Sent:* Tuesday, December 06, 2016 11:02 AM
> *To:* CIS-PIDD
> *Subject:* RE: [cis-pidd] Hyper IgA
>
>
>
> I had two sisters several years ago with a periodic fever picture who had
> very high levels of IgA. They eventually were diagnosed with hyper IgD
> syndrome.
>
>
>
>
>
> Peter B. Dent MD, FRCPC
>
> Professor, Pediatrics, McMaster University
>
> Division of Rheumatology & Immunology
>
> McMaster Childrens' Hospital
>
> 1280 Main St W. L8S 4K1
>
> Phone: 905-521-2100 ext 75382 <(905)%20521-2100>
>
> FAX: 905-521-4968 <(905)%20521-4968>
>
> E-mail: dentpb at mcmaster.ca
>
>
>
>
>
>
>
> *From:* CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org
> <cis-pidd at lists.clinimmsoc.org>]
> *Sent:* November-23-16 10:08 AM
> *To:* CIS-PIDD
> *Subject:* [cis-pidd] Hyper IgA
>
>
>
> I have followed a now 25 yo female with antibody deficiency and recurrent
> sinusitis with rare chest infections for 21 years. She is currently
> receiving IGSC 2.5g 6/7 days a week. She is followed by rheumatology for a
> non-deforming seronegative spondyloarthropathy and been getting Remicade
> for the past 18 months without much benefit. She is seldom infected and
> denies GI symptoms and diarrhea.
>
>
>
> Her IgA has been steadily increasing:
>
> Nov 17, 2016 - 925mg/dL
>
> Nov 11, 2016 - 803
>
> 2015 - 690
>
> 2005 - 320
>
> 1995 - 125
>
>
>
> Additional studies:
>
> Protein, Total, Serum 7.8 g/dL 6.0-8.5
>
> Albumin 3.5 g/dL 2.9-4.4
>
> Alpha-1-Globulin 0.3 g/dL 0.0-0.4
>
> Alpha-2-Globulin 0.7 g/dL 0.4-1.0
>
> Beta Globulin [H] 1.6 g/dL 0.7-1.3
>
> Gamma Globulin 1.7 g/dL 0.4-1.8
>
> M-Spike Not Observed g/dL Not Observed
>
> Globulin, Total [H] 4.3 g/dL 2.2-3.9
>
> A/G Ratio 0.8 0.7-1.7
>
> Immunofixation Result, Serum
>
> An apparent normal immunofixation pattern.
>
> Immunoglobulin G, Qn, Serum 1493 mg/dL 700-1600
>
> Immunoglobulin A, Qn, Serum [H] 925 mg/dL 87-352
>
> Results confirmed on dilution
>
> Immunoglobulin M, Qn, Serum 181 mg/dL 26-217
>
> LDH 159 IU/L 119-226
>
> Sedimentation Rate-Westergren [H] 51 mm/hr 0-32
>
> C-Reactive Protein, Quant [H] 8.2 mg/L
> 0.0-4.9
>
> I would appreciate any thoughts and recommendations for additional studies.
>
> Thanks,
>
> Richard Wasserman
>
> --
>
> Richard L. Wasserman, MD, PhD
> Allergy Partners of North Texas
> 7777 Forest Lane, Suite B-332
> Dallas, Texas 75230
> Office (972) 566-7788
> Fax (972) 566-8837
> Cell (214) 697-7211
>
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--
Saúl Oswaldo Lugo Reyes
Investigador en Ciencias Médicas
Unidad de Investigacion en Inmunodeficiencias
9° piso, Torre de Investigacion,
Instituto Nacional de Pediatria
Coyoacan 04530 DF, Mexico
+52(55)10840900 ext. 1866
--------------------------------------
"La penicilline guérit les humains; le vin les rend heureux"
"If penicillin cures sicknesses, Jerez resuscitates dead people". -Sir
Alexander Fleming
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