[CIS PIDD] [cis-pidd] Advice re: CD40L - should haploidentical donors be considered?

[CIS-PIDD]

Any reasonably sized cords available?  That may be a consideration as
well.
 
Dave
 
David Buchbinder, MD
Division of Hematology
CHOC Children's Hospital
 

>>> "CIS-PIDD" <cis-pidd at lists.clinimmsoc.org> 12/6/2016 4:07 PM >>>
Dear colleagues,
We would appreciate your advice with the following question: 
·		 In patients with mixed ethnicity with low likelihood of
finding matched-related and matched-unrelated donors, when (if ever)
would you consider moving to a T-cell reduced haploidentical donor? 
A brief case history is below: 
Our patient is a 4 yo M with confirmed XL-HIGM syndrome, who presented
classically in early childhood with PJP pneumonia. He has been infection
free with good growth for the past year and is maintained on weekly
SCIG, G-CSF to maintain normal neutrophil count, TMP-SMX for
pneumocystis prophylaxis, and cryptosporidium precautions. There is no
evidence of lung or liver disease at present. 
He is of mixed Asian and Caucasian background. A younger sib is not a
match. After 5 searches we remain unsuccessful in finding a match, and
suspect future searches will have low yield.
Thank you for your time – any feedback would be appreciated!


Dr. Victoria Cook MSc MD FRCPC
PGY-5, Allergy and Clinical Immunology
University of British Columbia
41-01536




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