[CIS PIDD] [cis-pidd] B-cell subsets

[CIS-PIDD]

Hi Joe,
Do the patients have normal numbers of B cells?
Best,
Jordan

From: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Reply-To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Date: Wednesday, February 1, 2017 at 2:34 PM
To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Subject: [cis-pidd] B-cell subsets

Colleagues:

Several of my CVID patients have displayed phenotypes similar to the following:

·         CD19+ IgD+ CD27- (naïve)                        20%

·         CD19+ IgD+ CD27+ (memory)                  48%

·         CD19+ IgD- CD27+ (switched memory    31%

Are there specific “CVID” genotypes that are likely to present with this pattern?

Joe Church
Children’s Hospital Los Angeles

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