[CIS PIDD] [cis-pidd] VS: Recurrent hand, foot and mouth disease with normal immune work up.
CIS-PIDD
cis-pidd at lists.clinimmsoc.org
Wed Feb 1 20:50:31 EST 2017
Thanks for your input
Monocytes are within normal limits
Ejaz
-----Original Message-----
From: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Sent: Wednesday, February 01, 2017 6:03 AM
To: CIS-PIDD
Subject: Re: [cis-pidd] VS: Recurrent hand, foot and mouth disease with normal immune work up.
Are monocytes/ DCs present (GATA2 deficiency)?
Philipp
*************
Philipp Henneke, MD
Professor, Head of Pediatric Infectious Diseases and Rheumatology Center for Pediatrics & Center for Chronic Immunodeficiency University Medical Center Freiburg Phone +49 (0)761 270-77640 Mobile +49 (0) 162 285 2481
Fax +49 (0)761 270-77600
philipp.henneke at uniklinik-freiburg.de
www.uniklinik-freiburg.de/cci/research/philipp-henneke.html
Postal address:
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the Center for Translational Cell Research (ZTZ) Breisacher Straße 115 · 79106 Freiburg · Germany
Don¹t miss on the event in innate immunity 2017
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Am 01.02.17 11:35 schrieb "CIS-PIDD" unter <cis-pidd at lists.clinimmsoc.org>:
>To add to Karl's list, a.o. STAT2 comes to mind as well, wondering also
>about the theoretical (animal data) possibility of a TLR3 pathway
>defect....
>
>...and 4 relapses make different strains from the environment and able
>to cause hand and foot phenotype rather unlikely of course, like the
>question already implies.
>
>Also: T cell subtyping, who deep an analysis was made? Are all mostly
>naives? RTE? Tg/d? (Here the lack of sufficient age-matched control
>group data causes a bit of difficulty.)
>
>Mikko
>
>BTW Karl: In our rather old material, recurrent HSV1 stomatitis seemed
>to be associated with HLA homozygosity...( Clin Infect Dis. 2001 Nov
>1;33(9):1604-7.) Have you ever been able to check for that? Would love
>to know if true or coincidental...
>
>Mikko Seppänen
>Head
>Hospital District of Helsinki and Uusimaa, Children's Hospital, Rare
>Disease Center P.O.Box 280, 00029 HUS |Lastenlinnantie 2, Helsinki
>Senior Consultant Hospital District of Helsinki and Uusimaa,
>Inflammation Center, Adult Primary Immunodeficiency Outpatient Clinic
>mikko.seppanen at hus.fi
>+358 9 47180201| +358 50 4279606
>faxi +358 9 47174703
>
>
>
>
>
>
>-----Alkuperäinen viesti-----
>Lähettäjä: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
>Lähetetty: 1. helmikuuta 2017 11:56
>Vastaanottaja: CIS-PIDD <cis-pidd at lyris.dundee.net>
>Aihe: RE:[cis-pidd] Recurrent hand, foot and mouth disease with normal
>immune work up.
>
>
>Dr. Yousef --
>
>Sounds very similar to the usual case I get of recurrent HSV-1
>stomatitis. Difference is, of course, you do not have the option of
>standing antiviral prophylaxis.
>
>I would suggest that the workup is not normal. I would recommend
>checking antiviral titers (rubella and varicella would be the easiest,
>if the child's vaccinated), the as well as doing the formal
>pneuomococcal polysaccharide vaccine challenge.
>
>I leave it to the more experienced members of the group to give a proper
>ranked differential. Though, of course, recurrent viral infection would
>lead one to look at the pure B cell defects, plus some SCIDs, NK
>defects, WHIM, and STAT1. If the patient actually does not mount a
>proper polysaccharide response (which may be the reason he needed the
>tympanostomy tubes to begin with), then it's a wider problem.
>
> - K
>
>
>Karl O. A. Yu, M.D., Ph.D., F.A.A.P.
>Section of Infectious Diseases | Department of Pediatrics | Comer
>Children's Hospital | University of Chicago
>5841 S Maryland Ave, MC 6054, Chicago IL 60637 Office phone:
>773-702-9281 | Pager: 773-702-6800 x1744 | Fax:
>773-702-1196
>
>________________________________________
>From: CIS-PIDD [cis-pidd at lists.clinimmsoc.org]
>Sent: Tuesday, January 31, 2017 3:28 PM
>To: CIS-PIDD
>Subject: [cis-pidd] Recurrent hand, foot and mouth disease with normal
>immune work up.
>
>Dear colleagues and experts: I would like to get your help on the
>following case:
>
>
>2-1/2-year-old with history of 4 episodes of hand, foot and mouth
>disease (in August 2015, September 2015, 08/01/2016 and 09/03/2016).
>Each episode presented with vesicles on the hands, feet and in the
>mouth associated with fever. The patient had a nasal swab on 09/01/2016
>that showed enterovirus. The patient was evaluated in this clinic on
>09/19/2016 and had immune work up that came back normal. Since last
>visit, John has done well without any medical problems till 01/07/2017,
>when he developed fever and vesicular rash on the hands, feet and the tongue.
>
>Past Medical History: The patient was born prematurely at 33 weeks'
>gestation and he stayed in the NICU for 8 weeks and he was diagnosed
>with apnea and bradycardia and gastroesophageal reflux. He has asthma
>and allergic rhinitis and he had recurrent illnesses and had
>tympanostomy tubes placement in March of 2016.
>
>
>
>Laboratory evaluation: On 09/19/2016, IgE 6, IgG: 598, IgA: 53, IgM:
>74, IgG 1: 372 , IgG2: 85, IgG3: 42, IgG4: 3.7, white blood cell count:
>10.6, poly 31%, lymph 57%, mono 8%, hemoglobin: 12.4, hematocrit: 36.6,
>platelets count: 422, Tand B cell subsets normal, pneumococcal titer
>with no response and tetanus antibody 1.56.
>
>Impression: Recurrent hand, foot and mouth disease with normal immune
>work up.
>
>Any suggestion regarding any further work up would be appreciated
>
>Ejaz Yousef MD
>Nemours Children Specialty Care
>Jacksonville, FL
>
>
>
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