[CIS PIDD] [cis-pidd] Adult CVID, Recurrent Shingles

[CIS-PIDD]

Colleagues:

I just started following an adult woman who was previously diagnosed with CVID.  She is doing very well with regards to respiratory and GI symptoms on weekly SCIg infusions.

However, she has experienced recurrent "shingles" and recently broke through valacyclovir prophylaxis.  The lesions have not been PCR'd for VZV.  She was told by another MD that a VZV vaccine may help.

I am a bit hesitant because she has a good VZV-specific lymphoproliferative response.

Assuming these are actually recurrent VZV outbreaks, has anyone noted an improvement in frequency or severity after administration of VZV vaccine?

Thank you for your time.

Joe Church
Children's Hospital Los Angeles



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