[CIS PIDD] [cis-pidd] Thymectomy and Hodgkin Disease

[CIS-PIDD]

Colleagues:



We are seeing a 19 year-old young lady who was born with tetralogy of Fallot.  During surgical correction thymectomy is part of the procedure.  She had a long history of recurrent otitis and at 17yo immunologic evaluation demonstrated borderline IgG, marginal antibody to pneumococcus, normal antibody to tetanus toxoid and Hib.  T-cells were 60% (874), B-cells 11% (156), NK cells26% (383).  She was not treated with Ig.



Seven months later she was diagnosed with EBV-positive Hodgkin disease.  She is currently in remission.



My question:  "Does neonatal thymectomy increase the risk for Hodgkin disease?"



Joe Church

Children's Hospital Los Angeles

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