[CIS PIDD] [cis-pidd] Live vaccines

[CIS-PIDD]

In the context of DiGeorge it has been proposed that live vaccines can be given to children >1 year of age if they have

·        CD8+ T cells are >300 cells/mm3

·        CD4+ T cells are >500 cells/mm3

·        antibodies to killed vaccine antigens demonstrated

·        normal or near-normal proliferative responses to mitogens and recall antigens (e.g. tetanus)

Alexandros Grammatikos

The Bristol NHS Immunology Allergy Centre

North Bristol NHS Trust, Pathology Building, Southmead Hospital,

Southmead Road, Westbury-On-Trym, Bristol BS10 5NB

Tel: 0117 414 8396 │ Fax: 0117 414 9386

 

From: cis-pidd at lyris.dundee.net [mailto:cis-pidd at lyris.dundee.net] On Behalf Of CIS-PIDD
Sent: 01 September 2017 22:28
To: CIS-PIDD
Subject: Re: [cis-pidd] Live vaccines

 

Some use a CD8 >250 as the parameter for routine vaccinations with live viruses. One could measure the response to other vaccines to get some measure of reassurance.

Richard Wasserman

Dallas

 

On Thu, Aug 31, 2017 at 9:50 AM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org> wrote:

A brief question - 

In the context of following many children with lymphocytopenia of varying degrees discovered via newborn screening, is there consensus on criteria  for resuming live vaccines?

 

Thanks!

 

Millard L. Tierce IV, DO, MBA, MS, FACAAI, FAAP

 

 

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-- 

Richard L. Wasserman, MD, PhD
Allergy Partners of North Texas
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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