[CIS PIDD] [cis-pidd] Neutropenia in XLA

[CIS-PIDD]

Dear all, w e have a 13 moths old boy with genetically confirmed XLA. At diagnosis he presented recurrent URTI, agammaglobulinemia and neutropenia. Despite immunoglobulin replacement therapy for 5 months with correct IgG levels (Ig G = 1300 mg/ dL ), mild to moderate neutropenia persists requiring intermittent G-CSF administration. Do you have any experience with long-term neutropenia in XLA? As far as I know neutropenia occurs at the time of diagnosis and it resolves after IgRT is started and normal IgG trough levels achieved. 

Best regards from BCN, 

P. 


Pere Soler Palacín, MD, PhD, MSc. 
Pediatric Infectious Diseases and Immunodeficiencies Unit. Hospital Universitari Vall d'Hebron. 
Vall d'Hebron Research Institute (VHIR) 
Assistant Professor. Universitat Autònoma de Barcelona (UAB) 
Director of the Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies (Barcelona) 
Pg. de la Vall d'Hebron, 119-129 
08035 Barcelona. Catalonia. 
Tel. 0034934893140 / Fax 0034934893039 
psoler at vhebron.net / 34660psp at comb.cat 
Web: www.upiip.com 
My ORCID 
ResearchGate: http://www.researchgate.net/profile/Pere_Soler-Palacin 
LinkedIn: www.linkedin.com/in/pere-soler-palacin 


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