[CIS PIDD] [cis-pidd] Negative Strep Antibodies in a Patient with Recurrent Strep

[CIS-PIDD]

Dear Joe,

About half of children that get strep throat do not develop ASLO or
antiDNAse-B antibodies (see ref at:
https://academic.oup.com/jid/article/188/6/809/943043/Immune-Response-to-Group-A-Streptococcal-C5a
)
Thus, I would not consider this as a sign of immune deficiency or favor
IVIG in this setting.

Arturo



*Dr. Arturo Borzutzky S.*
Profesor Asociado
Inmunología, Alergia y Reumatología Pediátrica
Departamento de Enfermedades Infecciosas e Inmunología Pediátrica
Escuela de Medicina, Pontificia Universidad Católica de Chile



On Wed, Oct 18, 2017 at 10:19 PM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org>
wrote:

> Colleagues:
>
> I follow a 15yo girl who has experienced multiple “strep throats.”  Most
> of these have been identified at the primary physician’s office with a
> positive rapid strep antigen test.
>
>
>
> However, anti-streptolysin O antibody and anti-DNase-B antibody have been
> negative.
>
>
>
> The patient has normal IgG (817), IgA (74) and IgM (121) levels and
> persistently positive (>1.3) antibodies to 23 of 23 *S. pneumoniae*
> serotypes (20 of these antibodies are >3.0) 2+ years from Pneumovax.
>
>
>
> Are the negative strep antibodies significant in this patient?
>
>
>
> Would these results justify a trial of Ig despite the very normal
> pneumococcal antibody responses?
>
>
>
> Thank you for your time.
>
>
>
> Joe Church
>
> Children’s Hospital Los Angeles
>
>
>
>
>
>
>
>
>
> CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,
> is for the sole use of the intended recipient(s) and may contain
> confidential
> or legally privileged information. Any unauthorized review, use, disclosure
> or distribution is prohibited. If you are not the intended recipient,
> please
> contact the sender by reply e-mail and destroy all copies of this original
> message.
>
> ---
>
> You are currently subscribed to cis-pidd as: drarturo at gmail.com.
>
> To unsubscribe click here: http://cts.dundee.net/u?id=96396494.
> 943ccbe7d743353df8f04330281beb58&n=T&l=cis-pidd&o=4622754
>
> (It may be necessary to cut and paste the above URL if the line is broken)
>
> or send a blank email to leave-4622754-96396494.
> 943ccbe7d743353df8f04330281beb58 at lyris.dundee.net
>

---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=4622766
or send a blank email to leave-4622766-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20171018/8009b8c6/attachment-0001.html>