[CIS PIDD] [cis-pidd] STAT1 gof

[CIS-PIDD]

Colleagues:

I have followed a 7yo girl who has experienced chronic oral candidiasis, recurrent pneumonias and failure to thrive.  She is on IVIG for poor antibody responses to routine immunizations.

We are strongly considering treating her with ruxolitinib.

Has anyone treated STAT1 gof with ruxolitinib in a patient this young?

Other than monitoring her clinically, is there any lab changes that could reflect response to the medication e.g. TH17 numbers, memory B-cell numbers and IgG4 levels.

I would appreciate any suggestions.

Thank you.

Joe Church
Children's Hospital Los Angeles

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