[PAGID] Lymphoma risk in subject with increased CD4/8 double positive cel ls and gene therapy with retroviral vector

[Fleisher, Thomas (NIH/CC/DLM)]

In our lab the upper limit of nomal for CD4+/CD8+ cells is 4.7% so 5% is
quite close to our range based on about 60 adult controls.  I do not know
the significance of elevated double positive T cells that we see on rare
occassion in non malignant patients.  Can't help in regard to Ron's
question.
Tom

Thomas A. Fleisher, M.D.
Chief, Department of Laboratory Medicine
Clinical Center, NIH, DHHS
301 496-5668 (Tel)
301 402-1612 (Fax)

> ----------
> From: 	Saxon, Andy, M.D.
> Reply To: 	pagid at clinimmsoc.org
> Sent: 	Monday, August 1, 2005 12:17 PM
> To: 	PAGID (E-mail)
> Subject: 	[PAGID] Lymphoma risk in subject with increased CD4/8 double
> positive cel ls and gene therapy with retroviral vector
> 
> I got the following message from our HIV program director. Anyone have any
> thoughts on this.  They are going to re-check the phenotyping this week.
> 
> Andy Saxon, 
> UCLA
> 
> >  -----Original Message-----
> > From: 	Mitsuyasu, Ronald, M.D.  
> > Sent:	Tuesday, July 26, 2005 4:08 AM
> > To:	Saxon, Andy, M.D.
> > Subject:	A question for you
> > 
> >   In the process of screening for our gene therapy trial in HIV, I have
> > come across an white male, about 45 years old, who has about 5% CD4 and
> > CD8 double positive lymphocytes.  Other than his HIV he is perfectly
> > health and has no childhood history of any immunologic or
> > lymphoproliferative disease.  I am wondering whether he might be at
> > greater risk for lymphoma or some other lymphoproliferative disease
> given
> > this, especially if we put him through a gene therapy treatment with a
> > retroviral vector and an anti-tat ribosyme gene (given the problems with
> > the SCID X1 patients in France.)  
> > 
> 
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