[PAGID] Lymphoma risk in subject with increased CD4/8 double positive cel ls and gene therapy with retroviral vector

[Saxon, Andy, M.D.]

I got the following message from our HIV program director. Anyone have any
thoughts on this.  They are going to re-check the phenotyping this week.

Andy Saxon, 
UCLA

>  -----Original Message-----
> From: 	Mitsuyasu, Ronald, M.D.  
> Sent:	Tuesday, July 26, 2005 4:08 AM
> To:	Saxon, Andy, M.D.
> Subject:	A question for you
> 
>   In the process of screening for our gene therapy trial in HIV, I have
> come across an white male, about 45 years old, who has about 5% CD4 and
> CD8 double positive lymphocytes.  Other than his HIV he is perfectly
> health and has no childhood history of any immunologic or
> lymphoproliferative disease.  I am wondering whether he might be at
> greater risk for lymphoma or some other lymphoproliferative disease given
> this, especially if we put him through a gene therapy treatment with a
> retroviral vector and an anti-tat ribosyme gene (given the problems with
> the SCID X1 patients in France.)  
> 

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