[PAGID] CVID with absent IgG

[Charlotte Cunningham-Rundles]

we have a group of these ---- it is always interesting how little Ig 
you can find in these adults

>A colleague of mine recently saw a 58 yo man with a history of 10+ years of
>recurrent pneumonia and one episode of bacterial sepsis. His QIG was IgA < 7
>mg/dL (nl 80-400), IgG <8 mg/dl (nl 690-1660). IgE ,0.1 IU/mL. IgM not done
>but "decreased" on IEP.  C3, C4, T and B cells % and # normal but CD4 28%
>with absolute 294 (normal 355-1426.)  Albumin 3.1 with nl 3.3-4.7
>
>I have seen a fair # of CVID in my time but I don't recall seeing one with
>an IgG this low...  What is your experience.
>
>Andy Saxon, UCLA


-- 


Charlotte Cunningham-Rundles MD PhD
Professor of Medicine, Pediatrics  and Immunobiology
Mount Sinai School of Medicine
1425 Madison Ave, New York 10029
phone 212 659 9268
fax  212 987 5593
Email:  charlotte.cunningham-rundles at mssm.edu