[PAGID] foxp3 ab

Wed May 10 08:19:32 EDT 2006

Sergio,

We have been using the eBioscience product for the past 8 months and
feel that it works well.  You could email Bosco in Sao Paulo (use his
old NIH email address) for his input as he has done most of the work.

Tom

Thomas A. Fleisher, M.D.

Chief, Department of Laboratory Medicine

Clinical Center, NIH

Bethesda, MD 20892-1508

Tel 301 496-5668

Fax 301 402-1612

________________________________

From: Sergio Rosenzweig [mailto:sdrosenzweig at yahoo.com] 
Sent: Tuesday, May 09, 2006 6:48 PM
To: pagid at clinimmsoc.org
Subject: [PAGID] foxp3 ab

Dear colleagues,

Does anybody can recommend me a reliable and commercially available
anti human foxp3 ab for flow?

Thanks in advance,

Sergio

Sergio D. Rosenzweig, MD

Servicio de Inmunologia

Hoapital Nacional de Pediatria "J. P. Garrahan"

Buenos Aires, Argentina

srosenzweig at garrahan.gov.ar

"Haines, Kathleen, M.D." <KHaines at humed.com> wrote:

	I had the same thought...and I've seen SOJA with low platelets. 

	Kathleen A. Haines, MD
	Section Chief, Pediatric Immunology
	Pediatric Rheumatology and Immunology
	Hackensack University Medical Center
	30 Prospect Ave.
	Hackensack, NJ 07601

	Tel: 201-996-5306
	Fax: 201-996-9815

	-----Original Message-----
	From: pagid-bounces at clinimmsoc.org
[mailto:pagid-bounces at clinimmsoc.org] On
	Behalf Of Christine Seroogy
	Sent: Wednesday, March 29, 2006 10:13 AM
	To: pagid at clinimmsoc.org
	Subject: Re: [PAGID] (no subject)

	Have you considered systemic JRA in this patient? Chris

	On Mar 29, 2006, at 8:37 AM, Sullivan, John (Office of Research)
wrote:

	> Colleagues; I need your help with a difficult case; Patient 
	> presented one year ago as a 2yo female from India; admitted
with 
	> fever, failure to thrive[ht and wt <3%], diffuse
lymphadenopathy, 
	> splenomegaly and arthralgias and history of intermittent
rashes; 
	> laboratory studies: WBC 17.4, Hgb 7.5, HCT 23, MCV 58, MCH
19.2, 
	> MCHC33, Platelets 54K, Differential, Neutophils
67%,Lymphocytes 
	> 28%,Monocytes 4%,Eosinophils 1%; ESR 48; IgG1780, normal IgA,
IgM, 
	> IgD, IgE; Total Hemolytic Complement normal; AST 74, ALT, 21,
LDH 
	> 1192, Tot Protein 6.2, Albumin 2.1, normal renal function;
elevated 
	> FDP and D- dimer, normal AT, compatible with active
fibrinolysis 
	> and early DIC; HIV serology negative; Bone Marrow, cellular
marrow, 
	> mild dyserythropoiesis, no evidence of malignancy, normal 
	> karyotype, normal T and B cells; Lymph Node Biopsy, reactive
lymph 
	> node with changes consistent with chronic stimulation and 
	> involution; Peripheral Blood, CD T Cells 78%, CD 4 T Cells
35%, CD 
	> 8 TCells 45%, CD 4/CD 8 0.78.
	>
	> Diagnoses: Immune Activation Syndrome secondary to ? viral 
	> infection; Alpha Thalassemia Trait
	>
	> Treatment: Begun in March 05 on Prednisone 2mg/kg/day with
slow but 
	> progressive improvement till al symptoms resolved except
continued 
	> HT and Wt <3%; tapered to 1mg/kg/day in August 05; then to QOD

	> prednisone; we were tapering off QOD regimen when over past
two 
	> weeks at 9mg QOD patient again started fevers, elevated ESR
and 
	> CRP, LFTs, albumin 2.8, Total protein 6.9; currently back on 
	> Prednisone 1mg/kg/day. Parents frustrated as are Dr and Nurse;
not 
	> sure what we are treating at this point; any help will be 
	> appreciated; thanks, John.
	>
	>
	>
	>
	>
	>
	> John L Sullivan MD
	> Professor of Pediatrics
	> University of Massachusetts Medical School
	> 55 Lake Avenue North
	> Worcester MA 01655
	> Phone 508-856-1572
	> Fax 508-856-5004
	> email john.sullivan at umassmed.edu
	>
	>
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