[PAGID] LAD and CMV

[Conley, Mary-Ellen]

Dear Lisa,
I think there are several variables that might influence your response.
One of the variables is the type of transplant.  If you were using an
unmanipulated sibling transplant, you might not worry too much if the
sibling were also CMV possitive.  If you are going to use a T cell
depleted transplant, you worry more.

Another variable is the state of the infection in the baby.  If urine is
CMV positive, you worry more.  I agree that use of gancyclorir (at least
2 weeks, therapeutic doses) is a good idea if you are worried.
Mary Ellen 




Mary Ellen Conley, MD
Department of Immunology
St. Jude Children's Research Hospital
332 N. Lauderdale
Memphis, TN 38105-2794
FAX  901-495-3977
TEL  901-495-2576


-----Original Message-----
From: pagid-bounces at clinimmsoc.org [mailto:pagid-bounces at clinimmsoc.org]
On Behalf Of Lisa Kobrynski, MD, MPH
Sent: Saturday, June 10, 2006 11:13 PM
To: pagid at clinimmsoc.org
Subject: [PAGID] LAD and CMV


We have a 4 month old with LAD1 who is going for transplant, but is CMV
PCR positive now (with some IgM and a little IgG).  
What is the experience with pre-transplant CMV in LAD patients?
Treatment?
Duration?

Thanks


Lisa Kobrynski, MD, MPH
Assistant Professor of Pediatrics
Division of Allergy and Immunology
Emory University
404-727-3575
404-727-5045 (fax)