[PAGID] lymphopenia

[Junker, Anne]

I agree.  In the interim, it might help to measure serum EBV load to see
if value is in the range associated with active EBV disease.
 
Anne Junker, MD
Associate Professor, Division of Infectious & Immunological Diseases,
Medical Director, Pediatric Specialty programs at BC Children's Hospital
Associate Director (Clinical), Child & Family Research Institute
Room K4-223
Children & Women's Health Centre 
4480 Oak Street, Vancouver, BC   V5H 3V4
Ph: 604-875-3591  Fx: 604-875-2414  email: ajunker at cw.bc.ca


-----Original Message-----
From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Kathleen E.
Sullivan
Sent: Tuesday, June 13, 2006 12:40 PM
To: pagid at list.clinimmsoc.org
Subject: Re: [PAGID] lymphopenia


When I hear Burkitts I think XLP.   Otehr features in your patient are
not very consistent but Lisa Filipovich will do testing for you.

On Jun 13, 2006, at 2:51 PM, Christine Seroogy wrote:

> Dear Colleagues,
>
> I would like to get your opinions about a 15y/o boy was admitted to
> our hospital with a gastrointestinal lymphoma (further
> characterization pending.)  He was initially seen in the immunology
> clinic here at 4 years of age because of severe primary VZV
> infection.  Evaluation at that time demonstrated
> lymphopenia--predominately CD4--and poor mitogen response.  His B cell
> numbers and function is normal (measured by titers to various vaccine
> antigens); he has been persistently hypergammaglobulinemic (IgG 1000s
> and IgA 400s).  NK cell numbers by CD16/56 slightly diminished.  HIV
> nonreactive.  He developed a Burkitt's lymphoma around age 10 and was
> successfully treated, he has had refractory sinus disease and
> recurrent OM.  No other infectious history or autoimmune phenomenon. 
> No relevant family history.  I welcome any thoughts on how to pursue a
> molecular diagnosis on this child or hearing  if you have seen similar
> cases.  Thank you,  Chris
>
>
>
>
>
> Chris Seroogy, M.D.
> Assistant Professor
> Dept. of Pediatrics
> Mail:  H4/474 CSC, Mailstop 4108
> Shipping:  H4/431 CSC, Mailstop 4108
> 600 Highland Ave.
> Madison, WI  53792
> phone: 608- 263-2652
> fax: 608-265-0164
>
>
Kathleen E. Sullivan MD PhD
Chief, Division of Allergy and Immunology
Associate Professor of Pediatrics
The Children's Hospital of Philadelphia
(p) 215-590-1697
(f) 215-590-3044

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