[PAGID] lymphopenia

[K. Scott Baker]

We have had 2 cases in the last couple of years, the first ended up having
XLP, the second we have been unable to molecularly characterize a defect, he
has a "CVID" phenotype.  Interestingly his lymphoma was metastatic Hodgkin's
at age 4, which recurred.  He is being treated for the recurrence and then
going to allo-HCT.  The XLP had several recurrences of his NHL (mainly
abdominal primaries).  He received non-myeloablative MSD BMT 2 yrs ago and
has had no evidence of his disease (or xlp) since.  Are you planning on HCT
for your patient? 

 

K. Scott Baker, MD, MS

Pediatric Blood and Marrow Transplant Program

University of Minnesota

420 Delaware St. SE, Mayo Bldg. Room D557

Mayo Mail Code 484

Minneapolis, MN 55455

612.625.4952  FAX 612.626.1434

baker084 at tc.umn.edu

  _____  

From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Christine Seroogy
Sent: Tuesday, June 13, 2006 1:51 PM
To: pagid at list.clinimmsoc.org
Cc: Kakumanu Sujani
Subject: [PAGID] lymphopenia

 

Dear Colleagues,

 

I would like to get your opinions about a 15y/o boy was admitted to our
hospital with a gastrointestinal lymphoma (further characterization
pending.) He was initially seen in the immunology clinic here at 4 years of
age because of severe primary VZV infection. Evaluation at that time
demonstrated lymphopenia--predominately CD4--and poor mitogen response. His
B cell numbers and function is normal (measured by titers to various vaccine
antigens); he has been persistently hypergammaglobulinemic (IgG 1000s and
IgA 400s). NK cell numbers by CD16/56 slightly diminished. HIV nonreactive.
He developed a Burkitt's lymphoma around age 10 and was successfully
treated, he has had refractory sinus disease and recurrent OM. No other
infectious history or autoimmune phenomenon. No relevant family history. I
welcome any thoughts on how to pursue a molecular diagnosis on this child or
hearing if you have seen similar cases. Thank you, Chris

 

 

 

 

Chris Seroogy, M.D.

Assistant Professor

Dept. of Pediatrics

Mail: H4/474 CSC, Mailstop 4108

Shipping: H4/431 CSC, Mailstop 4108

600 Highland Ave.

Madison, WI 53792

phone: 608- 263-2652

fax: 608-265-0164

 

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