[PAGID] lymphopenia

[Christine Seroogy]

Thank you all for the comments.  We are sending off blood for SAP  
flow today.  Regarding HCT, I can't answer that right now and will  
share this information with my heme/onc colleagues.  Chris



On Jun 13, 2006, at 9:32 PM, K. Scott Baker wrote:

> We have had 2 cases in the last couple of years, the first ended up  
> having XLP, the second we have been unable to molecularly  
> characterize a defect, he has a “CVID” phenotype.  Interestingly  
> his lymphoma was metastatic Hodgkin’s at age 4, which recurred.  He  
> is being treated for the recurrence and then going to allo-HCT.   
> The XLP had several recurrences of his NHL (mainly abdominal  
> primaries).  He received non-myeloablative MSD BMT 2 yrs ago and  
> has had no evidence of his disease (or xlp) since.  Are you  
> planning on HCT for your patient?
>
>
>
> K. Scott Baker, MD, MS
>
> Pediatric Blood and Marrow Transplant Program
>
> University of Minnesota
>
> 420 Delaware St. SE, Mayo Bldg. Room D557
>
> Mayo Mail Code 484
>
> Minneapolis, MN 55455
>
> 612.625.4952  FAX 612.626.1434
>
> baker084 at tc.umn.edu
>
> From: pagid-bounces at list.clinimmsoc.org [mailto:pagid- 
> bounces at list.clinimmsoc.org] On Behalf Of Christine Seroogy
> Sent: Tuesday, June 13, 2006 1:51 PM
> To: pagid at list.clinimmsoc.org
> Cc: Kakumanu Sujani
> Subject: [PAGID] lymphopenia
>
>
>
> Dear Colleagues,
>
>
>
> I would like to get your opinions about a 15y/o boy was admitted to  
> our hospital with a gastrointestinal lymphoma (further  
> characterization pending.) He was initially seen in the immunology  
> clinic here at 4 years of age because of severe primary VZV  
> infection. Evaluation at that time demonstrated lymphopenia-- 
> predominately CD4--and poor mitogen response. His B cell numbers  
> and function is normal (measured by titers to various vaccine  
> antigens); he has been persistently hypergammaglobulinemic (IgG  
> 1000s and IgA 400s). NK cell numbers by CD16/56 slightly  
> diminished. HIV nonreactive. He developed a Burkitt's lymphoma  
> around age 10 and was successfully treated, he has had refractory  
> sinus disease and recurrent OM. No other infectious history or  
> autoimmune phenomenon. No relevant family history. I welcome any  
> thoughts on how to pursue a molecular diagnosis on this child or  
> hearing if you have seen similar cases. Thank you, Chris
>
>
>
>
>
>
>
>
>
> Chris Seroogy, M.D.
> Assistant Professor
> Dept. of Pediatrics
> Mail: H4/474 CSC, Mailstop 4108
> Shipping: H4/431 CSC, Mailstop 4108
> 600 Highland Ave.
> Madison, WI 53792
> phone: 608- 263-2652
> fax: 608-265-0164
>
>
>

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