[PAGID] Granulomatous disease in CVID

[Kathleen E. Sullivan]

Out of desperation, I used MMF as a steroid sparing agent in one  
patient and it worked extremely well.
Kate
Kathleen E. Sullivan MD PhD
Chief, Division of Allergy and Immunology
Associate Professor of Pediatrics
The Children's Hospital of Philadelphia
(p) 215-590-1697
(f) 267-426-0363


On Aug 16, 2006, at 1:14 AM, Richard Steele wrote:

> Dear colleagues, I would appreciate your thoughts about the  
> following patient
>
> I have a 16 year old female with CVID and granulomatous disease  
> (lung infiltrates, hepatosplenometaly) Open lung biopsy showed non- 
> caseating granulomas, raised serum ACE. Responded well to  
> prednisone in 1998. Recent recurrence of the same disease, again  
> responded well to high dose prednisone (almost complete resolution  
> of pulmonary changes, reduction in hepatosplenomegaly)
>
> I am concerned that I will not be able to wean her off the  
> prednisone without further recurrence, any suggestions? I note case  
> reports using anti-TNF, is this what others are are using?
>
> Regards
>
> Dr Richard Steele
> Immunologist
> Wellington Hospital
> Riddiford St
> Private Bag 7902
> Wellington
> New Zealand
> 64 4 3855999
>
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