[PAGID] R: XLA Cord Blood

[dmvascon at usp.br]

I also agree in saving the cord, but I don't think that saving the  
cord or using cord blood for diagnosis are mutually exclusive.
For a flow cytometry we could use 1 ml and for molecular analysis 4 ml  
is enough. We had already done this in a family that had a previous  
IL-7R deficient SCID patient.

All the best,

Dewton

Citando "Notarangelo, Luigi" <Luigi.Notarangelo at childrens.harvard.edu>:


> I agree. I would save the cord

>

> Luigi D. Notarangelo

>

>

>

> -----Messaggio originale-----

> Da: pagid-bounces at list.clinimmsoc.org per conto di Sorensen, Ricardo

> Inviato: mer 20/06/2007 18.12

> A: pagid at list.clinimmsoc.org

> Oggetto: [PAGID] XLA Cord Blood

>

> Hi everybody,

>

>

>

> Mary Ellen and I thought that the following exchange of ideas may be of

> interest to you and elicit further comments and suggestions:

>

>

>

> Hi Mary-Ellen,

>

>

>

> I have an important question for you:

>

>

>

> We have a little patient with XLA that is going to have a brother in

> October (the parents were not interested in any form of ante-natal

> testing).

>

>

>

> We were preparing to arrange for a cord blood sample to check for B

> cells when the question came up if we should not save the cord for

> possible later use as stem cell source in case baby #2 is healthy AND

> HLA compatible. I do know that transplantation is not available jet, but

> I did not want to miss a possible opportunity to have a potentially

> ideal healthy stem cell source in the future.

>

>

>

> Should we even mention the possibility to save cord blood for the rather

> small possibility of having a healthy, HLA matched brother for an even

> less likely future use as a stem cell source?

>

>

>

> I would appreciate your opinion about this issue.

>

>

>

> Ricardo

>

>

> Hi Ricardo,

>

>

>

> I agree with you, I think it is a good idea to save the cord.  If the

> new baby is an HLA match, he might be a donor in the future.  If the new

> baby is affected, maybe the cord could be used for gene therapy.  We

> have used the center in Oakland for cord blood for our families.

>

>

>

> We usually have the family bring the new baby in by 6 weeks of age to

> evaluate and we try to start gammaglobulin before 10 weeks of age.

> About 10% of patients with sporadic XLA are hospitalized for infection

> at less than 6 months of age so we push for early therapy.

>

>

>

> Mary Ellen

>

>

>

> PS. I think you are right - cord blood collection might be a topic that

> elicited an interesting discussion.  Would you be willing to start it

> (just like your note to me - I've got a mom who is going to deliver.

> Should we use the cord for diagnosis or save it?).

>

>

>

>

>

>

>



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