[PAGID] Hyper IgE therapy?

[Richard L. Wasserman, M.D.,Ph.D.]

My personal experience is that fungal infection has been a common 
terminal event. Steroid use in these patients has been associated with 
fungal infection. I would add impiric anti-fungal therapy and work hard 
to minimize steroids. If there is an identified bacterial pathogen 
passive immunization with IVIG may be helpful.
Richard Wasserman

Saxon, Andy M.D. wrote:


>We have just received an very ill 28 yo man with alleged Hyper IgE ID who is septic, dic etc. My question is:

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>"Is there any immune directive intervention that is useful in this disease in general?"  

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>He is receiving excellent agressive regular medical management and unfortunately is on a necessary dose of steroids. I'm not aware of any proven cytokine, hematopoetic factor etc that has been shown to improve the underlying immune problem.

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>You rapid input even to say nothing new is out there would be greatly appreciated.

>

>Andy Saxon, MD

>UCLA 

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