[PAGID] ID diagnosis

[Bodo Grimbacher]

Javier,
although somewhat invasive, the bone marrow B cell subset as done (and 
published) by e.g. van Dongen in Rotterdam might be reveiling...
Yours, Bodo

> I have seen a 14 month-old girl with history of recurrent upper respiratoy infections, with one kidney (the other dysplastic detected in utero and not found posnatal), borderline low IgG, normal IgA and IgM, B cells 1% of lymphocytes (repeated and confirmed), CD4 65%, CD8 15%, NK 15%. Total lymphs 3,600/uL. Height 10 percentile, weight 3 percentile. Not dysmorphic. She has an aunt with history of having one kidney and receiving "immunoglobulin shots", and also she had a splenectomy because "it was not working". 

> The father of this child is Caucasian and the mother is from Mexico.

> I am measuring reponse to vaccines and will follow up B cells

> Any suggestion regarding diagnosis is appreciated. Thank you.

> Javier

>

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