[PAGID] CGD pregnancy

[Kari Nadeau]

Dear Jordan,

I recently had a 20 yo patient with AR CGD deliver a FT healthy girl and she
remained on septra, itra, clinda and keflex (we needed double coverage for
her) throughout the pregnancy and did extremely well. We weighed the risks
and the benefits and thought it prudent, in this woman's case, to continue
her prophylaxis given her history of severe infections.

Please feel free to contact me for any questions.
All the best,
Kari

On Feb 5, 2008 9:31 PM, Jordan Orange <orange at mail.med.upenn.edu> wrote:


> Dear Colleagues,

> I currently have a 27yo patient with autosomal recessive CGD who would

> like become pregnant.

>

> Does anyone have experience with this situation?

>

> I have many concerns.

>

> One small, but practical concern is that both TMP/SMX and itraconazole are

> pregnancy category C.  If she were to become pregnant, is there an

> acceptable alternative prophylactic regimen which would be safer for the

> fetus?  Alternatively, should TMP/SMX and itraconazole be continued?

>

> This patient and her family have an appropriate fear of CGD, as her

> younger sister died of fungal pneumonia 3 years ago.

>

> Thank you for reading this message and for any advice you might be able to

> offer.

>

> Best regards,

>

> Jordan

>

>  Jordan Orange MD/PhD

> Assistant Professor of Pediatrics

> University of Pennsylvania School of Medicine

> Children's Hospital of Philadelphia, Division of Immunology

> 3615 Civic Center Blvd,  ARC-1016H

> Philadelphia, PA 19104

> (Voice) 267-426-5622

> (Fax) 267-426-5727

> www.orangelab.org

>

>

>

>

>



-- 
Kari Nadeau, MD, PhD
Academic Faculty, Stanford Medical School
Division of Pulmonary, Allergy and Critical Care
Director, Allergy Clinics, Stanford Medical Center and Lucile Packard
Children's Hospital
Fax: 650-498-5560
Phone: 650-723-5227
knadeau at stanford.edu

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