[PAGID] CGD pregnancy

[Jordan Orange]

Dear Colleagues,

I currently have a 27yo patient with autosomal recessive CGD who  
would like become pregnant.

Does anyone have experience with this situation?

I have many concerns.

One small, but practical concern is that both TMP/SMX and  
itraconazole are pregnancy category C.  If she were to become  
pregnant, is there an acceptable alternative prophylactic regimen  
which would be safer for the fetus?  Alternatively, should TMP/SMX  
and itraconazole be continued?

This patient and her family have an appropriate fear of CGD, as her  
younger sister died of fungal pneumonia 3 years ago.

Thank you for reading this message and for any advice you might be  
able to offer.

Best regards,

Jordan

Jordan Orange MD/PhD
Assistant Professor of Pediatrics
University of Pennsylvania School of Medicine
Children's Hospital of Philadelphia, Division of Immunology
3615 Civic Center Blvd,  ARC-1016H
Philadelphia, PA 19104
(Voice) 267-426-5622
(Fax) 267-426-5727
www.orangelab.org




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