[PAGID] Cylex test

[MacGinnitie, Andrew]

I wonder if anyone is using or has thoughts on this test

 

http://www.cylex.net/assayprinciple.html

 

Basically it is a simplified, automated mitogen stimulation of CD4
cells.  It apparently is fast (24 hours or less) and requires much less
blood than traditional proliferation assays.  At our institution it is
also done in-house whereas we have to send out traditional proliferation
assays

 

Our bone marrow transplantation colleagues are using it routinely
because it is so convenient and it is apparently also being marketed to
guide immunosupression after solid organ transplant.  

 

I often struggle about whether I need to send proliferation on a kid who
I don't have a super-high suspicion (e.g. DiGeorge with low, but present
T-cells) and wonder if this might not be a better alternative


Andy

 

Andrew J. MacGinnitie MD PhD

Assistant Professor of Pediatrics

Division of Pulmonary Medicine, Allergy and Immunology

Children's Hospital of Pittsburgh

3705 Fifth Ave, Pittsburgh, PA 15213

andrew.macginnitie at chp.edu

412/692-8903 (office)

412/692-8499 (fax)

 

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