[PAGID] Patient with recurrent abscesses

[Oner Ozdemir]

In the literature (below); neutrophil PK deficiency described earlier with
recurrent staph infections.

*Burge PS*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Burge%20PS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>,
*Johnson WS*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Johnson%20WS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>,
*Hayward AR*<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Hayward%20AR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus>
.Neutrophil pyruvate kinase deficiency with recurrent staphylococcal
infections: first reported case.Br Med J. 1976 Mar 27;1(6012):742-5. A woman
with an intracellular killing defect in the neutrophils had neutrophil
pyruvate kinase deficiency. She had had recurrent staphylococcal infections
throughout her life. The enzyme present was unstable and its kinetics were
abnormal.PMID: 4193 [PubMed - indexed for MEDLINE].. PMCID: PMC1639201

Öner Özdemir, MD
Assoc. Prof. Pediatrics
Sema Teaching and Training Hospital (Private)
Dragos, Maltepe-Kartal, İSTANBUL -TÜRKİYE



On 7/18/08, Abraham, Roshini S., Ph.D. <> wrote:

>

>  We have a 43 year old woman from the Northwest United States that has had

> recurrent staphylococcal abscesses (non-MRSA) since age 9.  These have been

> located in her groin, under and on her arms, abdomen, behind her ear and

> generally develop within 12-24 hours.  She has required multiple incision,

> drainage, and packing procedures and has take prophylactic antibiotics

> without significantly decreasing the frequency of their occurrence.  She is

> otherwise healthy except for cigarette smoking, peripheral vascular disease,

> urinary stress incontinence, and irritable bowel syndrome.  She denies

> eczema.  Her father, his sisters, and her paternal grandmother all have the

> same problem though to a lesser degree.  Physical exam is notable only for 1

> cm pink raised lesions in her groin area, none are actively draining or

> fluctuant.  Her immune testing to date includes normal IgA, IgM, and IgG.

> She has had a normal oxidative burst test and normal neutrophil chemotaxis.

> She does not have anemia, thrombocytopenia or neutropenia.  Her ALC is also

> normal.  No evidence of respiratory or other infections, lymphadenopathy,

> malnutrition etc.

>

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> We would appreciate your comments and advice.

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> Mathew A. Rank, MD, Mayo Clinic, Rochester, MN

>

> Roshini S. Abraham

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> Roshini Sarah Abraham, Ph.D., D(ABMLI)

>

> Consultant, Div. of Clinical Biochemistry & Immunology

> Assistant Professor of Medicine & Lab. Medicine & Pathology

> Director

> Cellular and Molecular Immunology Laboratory

> Department of Laboratory Medicine and Pathology

> Hilton 210 e

> Mayo Clinic

> 200 1st St SW

> Rochester, MN-55905

> Ph: 507-266-9292

> Ph (Secy): 507-284-4055

> Fax: 507-266-4088

>

>

>




-- 
Öner Özdemir, MD
Assoc. Prof. Pediatrics
Sema Teaching and Training Hospital (Private)
Dragos, Maltepe-Kartal, İSTANBUL -TÜRKİYE
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