[PAGID] Wiskott-Aldrich study

[Richard L. Wasserman]

Jordan,
Thanks for the invitation. At this time, I have no untransplanted Wiskotts.
Richard

Jordan Orange wrote:

> Dear Colleagues,

>

> We have recently received IRB approval and an IND from the FDA to 

> begin a Phase-I safety and tolerability study of IL-2 in The 

> Wiskott-Aldrich syndrome.

>

> We are currently looking for collaborators and patients for our study.

>

> Our study is motived by the observation that in Wiskott-Aldrich 

> syndrome NK cell function and actin dynamics can be restored ex vivo 

> by exposure to IL-2.

>

> The study consists of three 5 day courses of low-dose IL-2 

> administered subcutaneously over 9 months.  It is intended for 

> patients who do not have plans for hematopoietic stem cell 

> transplantation.  The study will involve 3-5 visits to the Children's 

> Hospital of Philadelphia.  One will include an inpatient stay in our 

> Clinical and Translational Research center for the duration of the 

> initial IL-2 treatment cycle.  Others will include shorter stays. 

>  Patient travel will be supported by the study.

>

> Details of the study with inclusion and exclusion criteria as well as 

> protocol information (blood draws, visit timeline, etc.) can be found 

> on ClinicalTrials.gov at:

> http://clinicaltrials.gov/ct2/show/NCT00774358 

>

> Additional detail and protocol information is available at 

> www.wastherapy.com <http://www.wastherapy.com>

>

> Please contact us if you have any interest or questions.

>

> Thank you for reading this email,

>

> Jordan

>

> Jordan Orange MD/PhD

>

> University of Pennsylvania School of Medicine

>

> Children's Hospital of Philadelphia, Division of Immunology

>

> 3615 Civic Center Blvd,  ARC-1016H

>

> Philadelphia, PA 19104

>

> (Voice) 267-426-5622

>

>

> Sumita Roy-Ghanta, MD

> Instructor, Allergy and Immunology

> 34th and Civic Center Boulevard

> Orange Laboratory, Abramson Research Building 1016

> Philadelphia, PA 19104

> (Voice): 267-426-7772

> Email: ROYGHANTAS at email.chop.edu <mailto:ROYGHANTAS at email.chop.edu>

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