[PAGID] Use of Rituximab in opsoclonus-myoclonus syndrome

[Nicholas Rider]

Dear Eleonora,

We currently care for a 2 year old with OMS.  She presented 6 months  
ago with disabling eye movements causing regression of her motor  
development and she could no longer walk.  We treated her with a  
combination of ACTH, Rituximab and IVIG/SqIG.  She is now walking  
again and has few signs of OMS.  Upon making the diagnosis, we  
contacted Dr. Michael Pranzatelli (pranzatelli at siumed.edu;  
215-545-7635) of Southern Illinois University School of Medicine; he  
follows a large cohort of patients with this disorder and has created  
a treatment protocol for OMS.

I hope this is helpful to you and your patient.

Best Wishes,

Nick

Nicholas L. Rider, D.O.
Clinic for Special Children
535 Bunker Hill Road
Strasburg, PA 17579
Ph:  717-687-9407
Fx:   717-687-9237
nrider at clinicforspecialchildren.org



On Feb 2, 2009, at 4:22 AM, Eleonora Gambineri wrote:


> Dear all,

>

> I was asked from the neurology department of my hospital to give an  

> opinion regarding treatment with Rituximab in opsoclonus-myoclonus  

> syndrome. I have checked in the literature and there are few reports  

> describing a beneficial effect of Rituximab in combination with  

> IVIG. Although there is no clear indication on how to perform this  

> treatment. Usually Rituximab is given once a week for 4 weeks,  

> sometime is given for 4 weeks but not always IVIG are started right  

> after and are not given monthly as in hypo/agammaglobulinemia? When  

> would you start IVIG?

>

> Any thoughts or suggestions will be kindly appreciated.

>

> Best wishes,

> Eleonora

>

> *******************************************************************

> Dott.ssa Eleonora Gambineri

> Ricercatore Universitario

> Universita' degli Studi di Firenze

> Dipartimento di Pediatria-Ospedale Pediatrico "Anna Meyer"

> Viale Gaetano Pieraccini, 24

> 50139 FIRENZE

> Tel 055 5662405 (ufficio)

>        055 5662464 (lab)

> Fax 055 4221012

> e-mail: eleonora.gambineri at unifi.it; e.gambineri at meyer.it

>

> Eleonora Gambineri, MD

> Researcher/Assistant Professor

> University of Florence

> Department of Pediatrics-"Anna Meyer" Children's Hospital

> Viale Gaetano Pieraccini, 24

> 50139 FIRENZE

> ITALY

> Tel +39 055 5662405 (office)

>        +39 055 5662464 (lab)

> Fax +39 055 4221012

> e-mail: eleonora.gambineri at unifi.it; e.gambineri at meyer.it

> ********************************************************************

>

>

>

>

>


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