[PAGID] sterile granuloma in NBS1?

[Chinen, Javier]

Dear Dr. Kirkpatrick, Jack, Chris, 
I very much appreciate your interest and suggestions.
Wegener's was early in our differential, our pathologists ruled it out based on lack of vascular compromise. We didn't measure antibodies since he is IVIG dependent.
We have done cultures aerobic, anaerobic, fungal and AFB from every site at least twice each site now, without any organism recovered or seen in the staining. I asked our pathologists to take a second look at the first biopsy, and it was only when a fellow spent some time looking at the slides that she saw the rare AFB, actually FITE. We have not studied the IFN-g/IL12 axis, considering that at this time we are not sure this is a mycobacterial infection.
Have tried the Nijmegen center though a different person with no response, will try your suggestion
Thanks 
Javier





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