[PAGID] sterile granuloma in NBS1?

[Sabiha Anis]

Dear Dr Javier

 

Could it be sarcoidosis?

 

Regards

 

Sabiha Anis

Sindh Institute of Urology and Transplantation (SIUT), Pakistan
 

> From: jxchinen at texaschildrens.org

> To: pagid at list.clinimmsoc.org

> Date: Fri, 29 May 2009 13:18:12 -0500

> Subject: Re: [PAGID] sterile granuloma in NBS1?

> 

> 

> Dear Dr. Kirkpatrick, Jack, Chris, 

> I very much appreciate your interest and suggestions.

> Wegener's was early in our differential, our pathologists ruled it out based on lack of vascular compromise. We didn't measure antibodies since he is IVIG dependent.

> We have done cultures aerobic, anaerobic, fungal and AFB from every site at least twice each site now, without any organism recovered or seen in the staining. I asked our pathologists to take a second look at the first biopsy, and it was only when a fellow spent some time looking at the slides that she saw the rare AFB, actually FITE. We have not studied the IFN-g/IL12 axis, considering that at this time we are not sure this is a mycobacterial infection.

> Have tried the Nijmegen center though a different person with no response, will try your suggestion

> Thanks 

> Javier

> 

> 

> 

> 

> 

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