[PAGID] two questions on enteritis

[YaeJean Kim]

Dear all,

 

I am YaeJean Kim who attended the 2007 PID summer school while I was a
fellow in Seattle and now am relocated to Seoul, Korea. 

 

I see a patient in my institute and have questions as below. 

 

This is a now 18 month boy who is suspected for IPEX or IPEX like syndrome.
He has had intractable diarrhea, recurrent infections including pneumonia
and anal infection, fistula, hypothyroidism (only endocrinopathy
manifestiation he has) since age of 1 month. His brother died too with
similar features. 

 

He was initially presented with failure to thrive. Intestinal biopsy (at the
age of 7 mo) was suspected for IPEX but FOXP3 mutation was not observed.
Because of severe anal fistula, he received cecostomy. He is now on
azathioprine by our GI guy who is the main doctor for him. He still seems to
have frequent infection with fevers and get hospitalized for antibiotics. Do
you have any suggestions? Or should we repeat the test? All the tests were
done about 10 months ago. 

 

I would appreciate any feedback. Thanks a lot.  

 

 

Jean

 

--------------------------------------------

 

YaeJean Kim, MD

 

Assistant Professor 

50 Ilwon-dong Gangnam-gu

Division of Infectious Diseases

Department of Pediatrics

Samsung Medical Center

Sunggyungwan University

Seoul, 135-710

South Korea

tel) 82-2-3410-3539, 0987

fax) 82-2-3410-0043

yaejeankim at skku.edu

 

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