[PAGID] Autoinmmune enteropathy?
Nacho Gonzalez
nachgonzalez at gmail.com
Mon Aug 10 09:52:55 EDT 2009
normal stool D/R. worm infestations ruled out
Nacho Gonzalez Granado
2009/8/10, Sabiha Anis <sabiha_anis at hotmail.com>:
>
> What are the results of stool D/R. Have you ruled out worm infestations?
>
> Regards
> Sabiha anis
>
> ------------------------------
> Date: Fri, 7 Aug 2009 14:00:55 +0200
> From: nachgonzalez at gmail.com
> To: pagid at list.clinimmsoc.org
> Subject: [PAGID] Autoinmmune enteropathy?
>
> 7 year old female (RM) with severe chronic diarrea with neonatal onset.
> Cuacasian. She has persistent malabsortion. She required parenteral
> nutrition when she was eighteen month old (for severe malnutrition).
> Intestinal biopsy (2002): moderate partial vellous atrophy.
>
>
>
> Her sister (AM) suffers from refractory celiac disease (CD) with persistent
> antigliadin and antitransglutaminase positive despite strictly gluten free
> diet.
>
>
>
> The patient (RM) presents negative celiac serology. HLA is not compatible
> with celiac disease. Intraepitelial lymphocytes are not compatible with
> CD (in 2002 and now). Antienterocyte antibodies are also negative (in 2002
> and now). CD25+ and FOXP3+ are in normal range (this month). She has
> persistent IgE elevation (around 1000 IU/mL). Anti TPO levels were slightly
> elevated once (Dec´08) but now are in normal range. Anti PCA (parietal cell
> antibodies are slightly positive: 1/80 ) ANA + 1/40 (normal) . We have
> ruled out food allergies. IgG,A,M normal. Lymphocyte subpopulations:
> normal.
>
> She is now admitted for severe diarrhea and malnutrition.
>
>
>
> We are not sure about starting steroid therapy. We'd really appreciate
> helpful suggestions about diagnosis and treatment.
>
> ------------------------------
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