[PAGID] CGD patient

[grumach at usp.br]

Dear


I have just diagnosed CGD in a 3 month old male. He had prolonged  
fever with unknown origin and BCG vaccination was not looking well. He  
developed seizures and liquor showed about 600 cells, predominantly  
lymphomono, high protein and low sugar. No positivity was obtained in  
the cultures (for BCG still going on).
He received drugs for all possibilities: Amphotericin, Isoniazide,  
Pirazinamide, ryphampicin, co-trimoxazole and antibiotics. The fever  
and seizures disapeared after the 3rd day. BCG lesion is still present  
(same aspect). The cerebrospinal fluid (after 30 days) presents 73  
cells, lymphomono, high protein, low glucose and a previous positive  
ADA.
I would suggest to change pirazinamide for ethambutol.
Do you have any suggestion?

Thanks a lot

Best regards

Anete S Grumach, MD, PhD
Outpatient group of Primary Immunodeficiencies,
Dept of Dermatology, University of São Paulo
Dept of Immunization, Adverse Events, Secretary of Health, São Paulo