[PAGID] progressive loss of hearing in 6 year old boy

[C. Lucy Park]

------------------------------
*From:* Yoo, Tai June
*Sent:* Fri 11/09/2009 18:13

 Dear Prof.Walter

Your patient seems to have an autoimmune hearing  loss. Usual immunologic
test does not reveal much. You have to do ear disease specific tests.
Thereare some.

In Munchen  Prof Wolfgang Arnold, used to be a HEad of ENT Dept. of one of
the med schoolHe is an expert in this area. pleaase consult with him. Also
for blood test, please call Prof Jean Paul Tomasi, Chritian uni of Leuvin in
Brussel.head of Autoimminity lab. He can measure anti Po, anto cochlin
antibody level, also antotype II collAGEN ANTIBODY level also.

You could treat with steroid, antiTNF alpha, now I have treated one patient
with autologous stem cells,she is responding well...study in progress.

Jean Paul Tomasi...tel #32-2-721-0327.

Good luck. I will be happy to help you out.

Sincerely,


T.J.Yoo,M.D.,Ph.D.
Professor,
Medicine(rheumatology/allergy/immunology).
Molecular sciences, Otolaryngology
Univ. of Tennessee,memphis,Tn. 38163



-- 
C. Lucy Park, MD
Head, Division of Allergy-Immunology-Pulmonology
Dpt of Pediatrics
University of Illinois at Chicago
840 S. Wood St., Suite1306
Chicago, IL 60612
Tel: 312-996-6714
Fax: 312-413-8694


On Thu, Sep 10, 2009 at 8:11 AM, Walther, Joachim-Ulrich Prof.Dr. <
Ju.Walther at med.uni-muenchen.de> wrote:


>  To whom it may concern

>

> Dear colleagues,

>

> in the hope to direct my inquiry properly and adequately I put the

> following question to clinicians and immunologists involved in acquired

> deafness.

> I shall be extremely grateful for your comments and advice

>

> *Case:*

> Six year old boy, otherwise apart from mild gross motor retardation

> healthy.

> Left ear found to be nearly completely deaf at five years, apparently after

> an underestimated loss of function over the years. Neonatal hearing test

> normal.

> Now quickly developing (within a few months) loss of hearing

> contralaterally (low frequency spectrum). One course of steroid and osmotoc

> iv therapy given. During the few weeks since no improvement and no

> progression.    No family history, no consanguinity.

> Clinically unremarkable.

> No signs of inflammation and autoimmune activation in laboratory results.

> Ophthalmological findings normal.

> Audiologist´s interpretation:    autoimmune mediated loss of hearing.

> Advice: immunosuppressive therapy.

> Our question: is this indicated ?

> Genetic diagnosis is being considered, particularly to be able to avoid

> unnnecessary immunosuppression.

>

> Many thanks for your help

>

>   *Prof.Dr.med.J.-U.Walther M.Sc.*

> *Allgemeinpädiatrischen Ambulanz *

> *der Kinderklinik und Kinderpoliklinik*

> *im Dr.v.Haunerschen Kinderspital*

> *der Ludwig-Maximilians-Universität*

> *Lindwurmstraße 4*

> *80337  München*

> **

> *Tel.:    089 / 5160-2811*

> *Fax:      "        "   -7722*

> *mail:    **Ju.Walther at med.uni-muenchen.de*

>

>




-- 
C. Lucy Park, MD
Head, Division of Allergy-Immunology-Pulmonology
Dpt of Pediatrics
University of Illinois at Chicago
840 S. Wood St., Suite1306
Chicago, IL 60612
Tel: 312-996-6714
Fax: 312-413-8694
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