[PAGID] Synegis in transplant

[Berger, Melvin]

When we had RespiGam, the mean titer was 5x the titer in "regular" IGIV and the dose was 750 mg/kg. I do not know the titers of anti-RSV in current IGIV products. Hiowever, if you extrapolate from that, 400 mg/kg of "regular" IGIV does not provide the same protection as did RespiGam. Presumably, the concentration of Syngais would be adjusted to offer at least the same protection as its predeccesor.
 
Melvin Berger, M.D., Ph.D.
Professor of Pediatrics and Pathology
Case Western Reserve University
phone 216 844 3237
 
Director, Jeffrey Modell Center for Primary Immune Deficiencies
Division of Allergy-Immunology
Rainbow, Babies and Children's Hospital
University Hospitals of Cleveland
RB&C Rm 504, MS 6008B
11100 Euclid Ave.
Cleveland, OH 44106

________________________________

From: pagid-bounces at list.clinimmsoc.org on behalf of Richard Wasserman
Sent: Fri 10/23/2009 4:57 AM
To: PAGID
Subject: [PAGID] Synegis in transplant



Our stem cell transplanters posed the following question: Should their
patients, who get IVIG, 800mg/kg/mo while in the hospital and
400mg/kg/mo from discharge to evidence of B cell function, be given
Synegis as well? If so, is there an age cutoff when you would not give
it?
Thanks,
Richard Wasserman

--
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211




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