[PAGID] IVIG and endogenous antibody production

[raas0027 at umn.edu]

Hello everyone,

I am struggling to find data or literature (e.g. through OVID, PubMed) 
supporting the following statements that I find repeatedly in 
textbooks/journal review articles:


1. administration of passive antibodies [e.g. IVIG] to antigens that a 
patient has not previously encountered can suppress his or her endogenous 
capacity to produce antibodies


or in numerous patient-oriented websites:


2. '...If your child is receiving IVIG, there is a risk that it may 
interfere with the effectiveness of certain vaccines, even causing the 
vaccine to fail.'


Although these seem plausible, are any of you aware of published studies 
that demonstrate this with IVIG? I would love to read them.

I would also be interested in anecdotal comments.


Thanks,

Jason

-- 
Jason Raasch, MD

Midwest Immunology Clinic
15700 37th Ave N
Suite 110
Plymouth, MN 55446

(Phone) 763.577.0008
(FAX)   763.5770192