[PAGID] IVIG and endogenous antibody production

[Vinh, Donald (NIH/NIAID [F]]

Hi Jason,
For point #2: I cannot comment specifically on IVIG, but a similar phenomenon has been seen with maternal antibody levels at the time of vaccination. One study done in Peru awhile ago demonstrated that the higher the maternal antibody titers to measles virus were at the time of infant vaccination, the lower the likelihood of seroconversion (this was after 1 measles vaccine dose). On those same sera, we demonstrated that maternal antibody avidity had the same effect (i.e. higher maternal avidity in the pre-vaccination sample was associated with lower seroconversion and lower avidity produced post-vaccination). Not truly the same thing as IVIG but conceptually close, I think. Hope this helps. Would love to hear what others think.

Don

Donald C. Vinh, MD
Infectious Disease specialist & Medical Microbiologist
Visiting Post-doctoral Fellow, LCID
NIH / NIAID
9000 Rockville Pike
Bldg 10CRC, Rm B3-4141
Bethesda, MD     USA
20892
Ph: 301-496-2473
Fax: 301-480-4507
e-mail: vinhd at niaid.nih.gov

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From: raas0027 at umn.edu [raas0027 at umn.edu]
Sent: Tuesday, April 27, 2010 5:18 PM
To: pagid at list.clinimmsoc.org
Subject: [PAGID] IVIG and endogenous antibody production

Hello everyone,

I am struggling to find data or literature (e.g. through OVID, PubMed)
supporting the following statements that I find repeatedly in
textbooks/journal review articles:


1. administration of passive antibodies [e.g. IVIG] to antigens that a
patient has not previously encountered can suppress his or her endogenous
capacity to produce antibodies


or in numerous patient-oriented websites:


2. '...If your child is receiving IVIG, there is a risk that it may
interfere with the effectiveness of certain vaccines, even causing the
vaccine to fail.'


Although these seem plausible, are any of you aware of published studies
that demonstrate this with IVIG? I would love to read them.

I would also be interested in anecdotal comments.


Thanks,

Jason

--
Jason Raasch, MD

Midwest Immunology Clinic
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