[PAGID] IVIG and endogenous antibody production

[Sorensen, Ricardo]

Hi,

Clicical observations in two infants with hypogammaglobulinemia and
infections showed that giving monthly doses of 500 mg IgG kg did not
slow the development of IgM; IgG or IgA concntrations. The IgG
concentrations were monitored by keeping the dose and interval constant
through 4 to 9 months of age. IgG administration was stopped when we
calculated that the patients own production had reached normal
concentrations. 

Ricardo Sorensen  

-----Original Message-----
From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of raas0027 at umn.edu
Sent: Tuesday, April 27, 2010 4:19 PM
To: pagid at list.clinimmsoc.org
Subject: [PAGID] IVIG and endogenous antibody production

Hello everyone,

I am struggling to find data or literature (e.g. through OVID, PubMed)
supporting the following statements that I find repeatedly in
textbooks/journal review articles:


1. administration of passive antibodies [e.g. IVIG] to antigens that a
patient has not previously encountered can suppress his or her
endogenous capacity to produce antibodies


or in numerous patient-oriented websites:


2. '...If your child is receiving IVIG, there is a risk that it may
interfere with the effectiveness of certain vaccines, even causing the
vaccine to fail.'


Although these seem plausible, are any of you aware of published studies
that demonstrate this with IVIG? I would love to read them.

I would also be interested in anecdotal comments.


Thanks,

Jason

--
Jason Raasch, MD

Midwest Immunology Clinic
15700 37th Ave N
Suite 110
Plymouth, MN 55446

(Phone) 763.577.0008
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