[PAGID] primary cilia dyskinesia

[Mark Ballow]

Richard,

We published a study (Annal of Allergy 79:119, 1997) a number of years ago
of IVIG in patients with chronic inflammatory sinusitis. These patients
failed prophylactic antibiotics and had already had at least one surgical
procedure. patients had mild if any changes in Ig and 2 patients had "poor"
response to Pneumovax but we did not have the tools then to fully assess
pneumococcal responses. The rationale was to use the IVIG as
anti-inflammatory, not as replacement. We figured if we could save the child
an additional surgical procedure it was worth trying. We had good results in
5/6 patients. However, this was an open trial. Tried to get one of the IVIG
companies to fund a controlled trial but did not happen.Not sure whether
this approach would translate to patients with cilia dyskinesia.

Mark

Mark Ballow,MD
Allergy & Immunology Division
Women & Children's Hospital of Buffalo
SUNY Buffalo,School of Medicine
219 Bryant St
Buffalo, NY 14222
716-878-7105


On Wed, Aug 11, 2010 at 5:18 PM, Richard Wasserman <
drrichwasserman at gmail.com> wrote:


> I saw a five year old girl with primary cilia dyskinesia who has been

> managed with nasal hygiene and rotating aerosolized tobramycin and

> vancomycin but continues to have chronic sinusitis and recurrent bronchitis.

> She has had one pneumonia in the past year. Any other management

> suggestions? Has anyone treated such patients with gamma globulin. This

> patient has had a normal evaluation in the past and has normal isotypes

> today. Additional studies are pending.

> Thanks,

> Richard Wasserman

> Dallas

>

> --

> Richard L. Wasserman, MD, PhD

> DallasAllergyImmunology

> 7777 Forest Lane, Suite B-332

> Dallas, Texas 75230

> Office (972) 566-7788

> Fax (972) 566-8837

> Cell (214) 697-7211

>




-- 
Mark Ballow,MD
Allergy & Immunology Division
Women & Children's Hospital of Buffalo
SUNY Buffalo,School of Medicine
219 Bryant St
Buffalo, NY 14222
716-878-7105
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