[CIS-PAGID] B cell lymphopenia and CMV associated cytopenia

[Pere Soler Palacin]

Dear all, we have a new patient (female 10 mo, without significant personal or familial history - no consanguinity-, and normal weight, height and head circumference ) with  severe B cell lymphopenia  (normal total lymphocy te count with 96%CD3+ -almost all alpha-beta - 0.3% CD19+ and 2-3% CD56+) and severe CMV infection with Coombs negative anemia and thrombo cytopenia . We are studying if it is congenital or not (by analysing CMV by PCR in blood spot card). 

T cell functional studies loooking for maternal engraftment and hypomorphic RAG mutations are normal (although we are still considering mutational analysis). 

B-cells are almost absent both in peripheral blood and bone marrow. Chest X-ray is normal. 



Would you consider Good syndrome in this patient despite the fact she is only 10 months? Any other suggestion? 





Waiting for your news. 



Pere 





Pere Soler Palacín, MD 

Pediatric Infectious Diseases and Immunodeficiencies Unit. 

Vall d'Hebron University Hospital 

Barcelona, Spain 



Waiting for your news. 



Pere 





Pere Soler Palacín, MD 

Pediatric Infectious Diseases and Immunodeficiencies Unit. 

Vall d'Hebron University Hospital 

Barcelona, Spain
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20101111/4fb07f6f/attachment.htm>