[CIS-PAGID] Duration of treatment for Crohn's in XLA

[Richard Wasserman]

He was given a ferret by his home IV nurse and developed diarrhea the was
positive for Giardia. he was treated, the Giardia eradicated and he never
got better. On biopsy he had granulomata of the terminal ileum that was read
out as Crohn's. He is my only XLA with chronic GI problems.
Richard

On Wed, Apr 6, 2011 at 4:54 PM, Kate Sullivan
<sullivak at mail.med.upenn.edu>wrote:


> I don't know the answer to your question and was surprised by the question.

>  I think of XLA as being more free from autoimmune disease than other immune

> deficiencies.  I wonder how common this is and wonder if this is perhaps a

> topic for some research investigation.

>

> Kate

> Kate Sullivan, MD PhD

> Professor of Pediatrics

> ARC 1216 Immunology CHOP

> 3615 Civic Center Blvd.

> Philadelphia, PA 19104

> (p) 215-590-1697

> (f) 267-426-0363

>

>

> On Apr 6, 2011, at 5:27 PM, Richard Wasserman wrote:

>

> > I have cared for this 23yo with XLA (BTK mutation confirmed) who has a

> ten year history of Crohn's. He has been maintained on azathioprine and has

> never been exposed to a biologic response modifier. When azathioprine was

> weaned about five years ago there was relapse. He has been doing very well

> since his remission was reinduced with prednisone. He now asks about

> stopping azathioprine. He has never had any other autoimmune diathases. Is

> there any experience with discontinuing treatment in XLA patients with

> Crohn's?

> > Thanks,

> > Richard Wasserman

> > Dallas

> >

> > --

> > Richard L. Wasserman, MD, PhD

> > DallasAllergyImmunology

> > 7777 Forest Lane, Suite B-332

> > Dallas, Texas 75230

> > Office (972) 566-7788

> > Fax (972) 566-8837

> > Cell (214) 697-7211

>

>



-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211
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