[CIS-PAGID] Achilles tendonitis with fluoroquinolone in CGD

[Kirkpatrick, Charles]

We had one patient rupture both Achilles tendons while taking Levaquin.

Chuck Kirkpatrick

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Richard Wasserman
Sent: Friday, May 27, 2011 7:38 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] Achilles tendonitis with fluoroquinolone in CGD

Tendonitis, particularly Achilles tendonitis is a well recognized side effect of fluoroquinolones (see boxed warned in each of the package inserts). We have seen this in several CVID patients and even presumed normals (including me).
Richard Wasserman
On Fri, May 27, 2011 at 8:29 AM, Newburger, Peter <Peter.Newburger at umassmed.edu<mailto:Peter.Newburger at umassmed.edu>> wrote:
A 14 y.o. boy with X-linked CGD has developed Achilles tendonitis after 1 week of treatment with ciprofloxacin and doxycycline for cervical lymphadenitis.   He had been maintained on his usual prophylactic itraconazole as well.
Does anyone else have experience with this complication?  I wonder if the toxicity, unusual at this age, was potentiated by the itraconazole.  Or could CGD predispose to this form of inflammation?
Thanks,
Peter
-------------------------------------------------------------
Peter E. Newburger, MD
Ali and John Pierce Professor of
     Pediatric Hematology/Oncology
Vice Chair for Research
Department of Pediatrics
University of Massachusetts Medical School
55 Lake Avenue North
Worcester, MA 01655
tel. 508 856-4225<tel:508%20856-4225>
fax 508 856-4282<tel:508%20856-4282>
peter.newburger at umassmed.edu<mailto:peter.newburger at umassmed.edu>
-------------------------------------------------------------





--
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20110527/e189698e/attachment.html>