[CIS-PAGID] Complement sequencing

[Fabrício Prado Monteiro]

Dra. Anete Grummach! USP-SP

Dr. Fabrício Prado Monteiro

Imunologista & Pediatra

HFA-Dep. de Alergologia

HRAS-Dep. de Pediatria.

Il giorno 06/giu/2011, alle ore 18:53, "Cunningham-Rundles, Charlotte" <charlotte.cunningham-rundles at mssm.edu> ha scritto:


> A long shot, but have seen a few older adults with severe and sudden ICU

> admissions ( looked like sepsis with need for intubation, ARDS etc)  who had

> a paraprotein buried in somewhat normal serum IgG levels. This looks like

> consumption more than genetics, right?

> 

> 

> Charlotte Cunningham-Rundles MD PhD

> Departments of Medicine, Pediatrics

> The Immunology Institute

> Mount Sinai School of Medicine

> 1425 Madison Avenue,

> New York City, New York, 10029

> 212 659 9268 (phone)

> 212 987 5593 (fax)

> 

> 

>> From: Sergio Rosenzweig <srosenzweig at garrahan.gov.ar>

>> Reply-To: PAGID <pagid at list.clinimmsoc.org>

>> Date: Mon, 06 Jun 2011 17:45:26 -0400

>> To: PAGID <pagid at list.clinimmsoc.org>

>> Subject: [CIS-PAGID] Complement sequencing

>> 

>> Dear All,

>> Are you aware of any commercial labs doing Complement (C1, C4, C2) sequencing

>> (in or outside the US)?

>> 

>> Brief story: Previously healthy 60yo male starting 2.5y ago with 3 consecutive

>> episodes (within 6m) of high fevers, elevated LFTs and acute lung bilateral

>> infiltrates/distress that took him to the ICU twice (no vent necessary),

>> improved on IV antibiotics but no microorganisms were ever isolated.

>> Serologies were neg or non contributory, in the context of NL Ig levels and

>> adequate response to protein and polysaccharide antigens. Interestingly, CH50

>> has remained undetectable since the 1st time checked 2y ago, AP50 is normal,

>> C1, C4 and C2 are very low or undetectable, CIC always normal, no skin, GI or

>> renal disease, no autoab detected, SedRate and CPR WNL, and no Ig or C

>> deposits at lung, liver or skin biopsies. After the original 3 episodes he

>> repeated 2 more, just with high fevers and transient LFT elevation. Never

>> placed on steroids, currently on prophylactic azithromycin since 1y ago.

>> Comments, questions and suggestions are more than welcome.

>> Thanks,

>> Sergio

>> 

>> 

>> Sergio D. Rosenzweig, MD, PhD

>> Chief, Infectious Diseases Susceptibility Unit

>> Laboratory of Host Defenses, NIAID, NIH

>> 10 Center Dr., Bldg. 10, CRC 5W-3888

>> Bethesda, MD 20892-1456

>> Phone (301) 451 8971

>> Fax (301) 451 7901

>> Cell (240) 361 7617

>> Pager 102 10678

>> srosenzweig at niaid.nih.gov

>> 

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>