[CIS-PAGID] Complement sequencing

[Prof. Dr. Antonio Condino Neto]

Contact Lourdes Isaac in Brazil

Lourdes Isaac <louisaac at icb.usp.br>,
-- 
Antonio Condino-Neto
Professor of Experimental Medicine
Institute of Biomedical Sciences, University of São Paulo
1730 Lineu Prestes Avenue, São Paulo - SP. ZIP 05508-000. Brazil
Tel (55) (11) 3091-7387 / Fax (55) (11) 3091-7224



Citando Sergio Rosenzweig <srosenzweig at garrahan.gov.ar>:


> Dear All,

> Are you aware of any commercial labs doing Complement (C1, C4, C2)  

> sequencing (in or outside the US)?

>

> Brief story: Previously healthy 60yo male starting 2.5y ago with 3  

> consecutive  episodes (within 6m) of high fevers, elevated LFTs and  

> acute lung bilateral infiltrates/distress that took him to the ICU  

> twice (no vent necessary), improved on IV antibiotics but no  

> microorganisms were ever isolated. Serologies were neg or non  

> contributory, in the context of NL Ig levels and adequate response  

> to protein and polysaccharide antigens. Interestingly, CH50 has  

> remained undetectable since the 1st time checked 2y ago, AP50 is  

> normal, C1, C4 and C2 are very low or undetectable, CIC always  

> normal, no skin, GI or renal disease, no autoab detected, SedRate  

> and CPR WNL, and no Ig or C deposits at lung, liver or skin  

> biopsies. After the original 3 episodes he repeated 2 more, just  

> with high fevers and transient LFT elevation. Never placed on  

> steroids, currently on prophylactic azithromycin since 1y ago.

> Comments, questions and suggestions are more than welcome.

> Thanks,

> Sergio

>

>

> Sergio D. Rosenzweig, MD, PhD

> Chief, Infectious Diseases Susceptibility Unit

> Laboratory of Host Defenses, NIAID, NIH

> 10 Center Dr., Bldg. 10, CRC 5W-3888

> Bethesda, MD 20892-1456

> Phone (301) 451 8971

> Fax (301) 451 7901

> Cell (240) 361 7617

> Pager 102 10678

> srosenzweig at niaid.nih.gov

>

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