[CIS-PAGID] post transplant BK infection

[Cowan, Mort]

Have they gotten a plasma BK PCR? If it's positive people have used
cidofovir with some success. If it's just in the bladder then usually
you just treat the hemorrhagic cystitis with hydration, looking to avoid
clot formation in the bladder, until it resolves on its own. This can
take several weeks. How severe is it? Are transfusions being required
and at what frequency? I suppose you could consider cidofovir if it's
severe enough even if not systemic infection. The issue, of course, is
the renal toxicity from cidofovir but probenecid protects the kidneys to
some extent.

 

Mort

 

Morton J. Cowan, M.D.

Professor of Pediatrics

Chief, Blood and Marrow Transplant Division

UCSF Children's Hospital, Room M659

505 Parnassus Ave

San Francisco, CA 94143-1278

 

Phone: 415-476-2188

FAX: 415-502-4867

 

**Confidentiality Notice** This email communication and any attachments
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From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Kirkpatrick,
Charles
Sent: Thursday, June 23, 2011 8:43 AM
To: 'pagid at list.clinimmsoc.org'
Subject: Re: [CIS-PAGID] post transplant BK infection

 

Richard:

 

I have a patient with CVID who was also on immunosuppression for her
renal transplant.  Her BK virus infection cleared when the transplant
team reduced her immunosuppressive treatment.  There were no adverse
effects on kidney function.

 

Chuck Kirkpatrick

 

From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Richard
Wasserman
Sent: Wednesday, June 22, 2011 3:09 PM
To: PAGID
Subject: [CIS-PAGID] post transplant BK infection

 

My heme/onc colleagues have transplanted a two year old AML in remission
who is now one month post-transplant and has reconstituted well. She
would be home at this time but for severe hemorrhagic cystitis due to BK
viral infection. Any suggestions?
Thank you,
Richard Wasserman

-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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