[CIS-PAGID] HSCT in CMC with polyendocrinopathy

[Richard Wasserman]

In early 1998, a then 15 year-old female who had presented at age two with
oral candidiasis and tetany, received a matched, related transplant from her
10 year-old brother. At the time of transplant she had established
hypothyroidism, hypoparathyroidism, hypoadrenalism, ovarian failure and
chronic hepatitis that, on biopsy was autoimmune vs drug. Prior to
transplant, oral and especially esophageal candidiasis were very difficult
problems; she had no other infections. It was hoped that transplant would
prevent the development of diabetes.

Her course has been complicated by an episode of brochiolitis obliterans
about one year post-transplant that responded well to high dose steroids and
gamma globulin, and, more recently, some chest infections. There have been
no new manifestations of autoimmunity. Perhaps this experience is
informative in the context of the current thread.
Richard Wasserman

-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211
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