[CIS-PAGID] quick question

[Routes, John]

thanks for the helpful responses






________________________________
From: Javier Chinen <chinej20 at hotmail.com>
Reply-To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
Date: Tue, 16 Aug 2011 12:13:24 -0500
To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
Subject: Re: [CIS-PAGID] quick question

Quality control for IVIG products required by the FDA includes measurement of antibody titers for tetanus, diphtheria, measles. Dropping titers for measles in IVIg products (and donors) in the last decade is a current concern.
The companies may include other antigens at their own initiative, such as parvovirus, hepatitis B.

Of interest, you might also find anti-HTLV I, anti-strongyloides antibodies.

Javier Chinen



________________________________
Date: Tue, 16 Aug 2011 09:44:18 -0700
From: JChurch at chla.usc.edu
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] quick question

The manufacturers do some titers e.g. tetanus and measles.



You could measure other antibodies in products directly after diluting appropriately.



We measured selective auto antibody titers in patients pre- and post-IVIG to show that IVIG infusions can result in positive anti-TPO antibodies (Pediatr All Immunol Pulmonol 2010; 23:121-3).



Joe Church

Children’s Hospital Los Angeles





-----Original Message-----
From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Sorensen, Ricardo
Sent: Tuesday, August 16, 2011 9:39 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] quick question



The companies have that information. Richard Schiff has been interested

in this issue in the past.



Ricardo Sorensen



-----Original Message-----

From: pagid-bounces at list.clinimmsoc.org

[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Routes, John

Sent: Tuesday, August 16, 2011 11:25 AM

To: pagid at list.clinimmsoc.org

Subject: [CIS-PAGID] quick question



I have a quick question--Is there a way to find out specific Ab titers

to

different Ags in commercially available IVIG or SCIG?

thanks



John M. Routes, MD

Chief, Section of Allergy and Clinical Immunology

Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics

Department of Pediatrics

Children's Hospital of Wisconsin

Medical College of Wisconsin

9000 W. Wisconsin Ave.

Milwaukee, WI  53226-4874



Phone: 414-456-4802; 414-266-6997

Fax: 414-456-6487 (Clinical)

Fax: 414-456-6323 (Laboratory)

Email: jroutes at mcw.edu







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